ea0063gp100 | Adrenal and Neuroendocrine - Basic | ECE2019
Weigand Isabel
, Schreiner Jochen
, Rohrig Florian
, Kiseljak-Vassiliades Katja
, Hofner Kerstin
, Kendl Sabine
, Fassnacht Martin
, Sbiera Silviu
, Kroiss Matthias
Background: Mitotane is the only drug approved for treatment of adrenocortical carcinoma (ACC). We have found that mitotane leads to endoplasmic reticulum stress and decreased viability in ACC cells. It is not known by which downstream mechanisms cell death is induced by mitotane.Aim: To characterize the mechanisms underlying cell death resulting from mitotane treatment in ACC cells.Methods: Lipid peroxidation in the ACC cell line ...